Serum and salivary adiponectin dynamics in septic and non-septic systemic inflammation in a canine model

Publication date: Available online 25 October 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Roman Dąbrowski, Anna Wdowiak, Maria D. Contreras-Aguilar, Lorena Franco-Martinez, Alberto Muñoz-Prieto, Marek Szczubiał, Silvia Martinez-Subiela, Jose J. Ceron, Asta TvarijonaviciuteAbstractAdiponectin is a 30 kDa protein hormone that has anti-atherogenic properties, being an insulin-sensitizing and anti-inflammatory molecule. Salivary adiponectin concentrations correlate positively with serum, thus, saliva was indicated as appropriate biofluid for its measurement in different clinical situations. However, inflammation was indicated as main confounding factor when evaluating the usefulness and the reliability of determination of salivary adiponectin. The aim of the present report was to evaluate the dynamics of salivary and serum adiponectin in systemic non-septic and septic inflammation using a dogs as a model. Forty bitches were enrolled. Seventeen dogs were healthy (group I, non-septic) and 23 bitches were diagnosed with pyometra (group II, septic). Ovariohysterectomy was performed for all animals. Saliva and blood samples were collected before (D0) and 3 (D3) and 10 (D10) days after ovariohysterectomy. At D0, Group I showed higher serum and salivary adiponectin than group II, although statistical significance was only detected in salivary adiponectin between the two groups at D0 (P = 0.001). In serum, adiponectin was higher on D0 than on D3 and tended to...
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research