Growth and Differentiation Factor 15 as a biomarker for mitochondrial myopathy

Publication date: Available online 26 October 2019Source: MitochondrionAuthor(s): Nanna Scharff Poulsen, Karen Lindhardt Madsen, Tessa Munkeboe Hornsyld, Anne-Sofie Vibæk Eisum, Freja Fornander, Astrid Emilie Buch, Mads Godtfeldt Stemmerik, Cristina Ruiz-Ruiz, Thomas Oliver Krag, John VissingAbstractObjectiveWe investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies.MethodsSerum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls.Results and conclusionsOur findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.
Source: Mitochondrion - Category: Biochemistry Source Type: research