Bayesian hypothesis testing with frequentist characteristics in clinical trials

Through the use of an informative prior, Bayesian methodologies could potentially borrow the strength of historical information and become more and more popular for their applications to clinical trials. Nonetheless, even with tremendous effort, the reconciliation of the formulation of the hypotheses and the calculation of type I error between a Bayesian analysis and traditional frequentist analysis is still not very clear. In this research, we apply an inferential prior, null prior and design prior to the Bayesian data analysis, type I error control and sample size calculation.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Source Type: research