Disruption of the Bone Morphogenetic Protein Receptor 2 Pathway in Nitrofen‐Induced Congenital Diaphragmatic Hernia

CONCLUSIONThe observed disruption of the BMPR2 signaling pathway may lead to extensive vascular remodeling and contribute to PH in the nitrofen‐induced CDH model. BMPR2 may therefore represent a potential target for the treatment of PH in CDH.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - June 1, 2013 Category: Perinatology & Neonatology Authors: Jan‐Hendrik Gosemann, Florian Friedmacher, Naho Fujiwara, Luis A. J. Alvarez, Nicolae Corcionivoschi, Prem Puri Tags: Original Article Source Type: research