An in silico parametric model of vertebrae trabecular bone based on density and microstructural parameters to assess risk of fracture in osteoporosis

In this study, an in-silico parametric model of vertebral trabecular bone incorporating both material and microstructural parameters was developed towards the accurate assessment of osteoporosis and the consequent risk of bone fracture. The model confirms that the mechanical properties such as strength and stiffness of vertebral trabecular tissue are highly influenced by material properties as well as morphology characteristics such as connectivity, which reflects the quality of connected inter-trabecular parts. The FE cellular solid model presented here provides a holistic approach that incorporates both material and microstructural elements associated with the degenerative process, and hence has the potential to provide clinical practitioners and researchers with more accurate assessment method for the degenerative changes leading to inferior mechanical properties and increased fracture risk associated with age and/or disease such as Osteoporosis.
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - Category: Biomedical Engineering Authors: Tags: Original Articles Source Type: research