NMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors

Conclusions: Overall, our work shows that NMP-7 mediates a significant analgesic effect in a model of persistent inflammatory and chronic neuropathic pain by way of T-type channel modulation and CB2 receptor activation. Thus, this study provides a novel therapeutic avenue for managing chronic pain conditions via mixed CB ligands/T-type channel blockers.

http://www.molecularpain.com/content/10/1/77

Source: Molecular Pain - December 6, 2014 Category: Molecular Biology Authors: N BergerVinicius GadottiRavil PetrovKevin ChapmanPhilippe DiazGerald Zamponi Source Type: research