Induction of membrane curvature by proteins involved in Golgi trafficking

Publication date: Available online 16 October 2019Source: Advances in Biological RegulationAuthor(s): Stefanie L. Makowski, Ramya S. Kuna, Seth J. FieldAbstractThe Golgi apparatus serves a key role in processing and sorting lipids and proteins for delivery to their final cellular destinations. Vesicle exit from the Golgi initiates with directional deformation of the lipid bilayer to produce a bulge. Several mechanisms have been described by which lipids and proteins can induce directional membrane curvature to promote vesicle budding. Here we review some of the mechanisms implicated in inducing membrane curvature at the Golgi to promote vesicular trafficking to various cellular destinations.

Source: Advances in Biological Regulation - October 17, 2019 Category: Biology Source Type: research