PRC2 Plays Red Light, Green Light with MHC-I and CD8+ T Cells

Publication date: 14 October 2019Source: Cancer Cell, Volume 36, Issue 4Author(s): Johnathan R. WhetstineIn this issue of Cancer Cell, Burr et al. report that PRC2 plays a conserved role in silencing antigen presentation and processing genes and, in turn, CD8+ T cell activation. Furthermore, PRC2-targeted therapeutics overcome gene silencing and promote tumor clearance by cytotoxic T cells.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research