A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability

In conclusion, our findings show that kindlin-3 not only activates and clusters integrins into podosomes but also regulates their lifetime by recruiting leupaxin, which controls PTP-PEST activity and thereby paxillin phosphorylation and downstream signaling.

http://jcb.rupress.org/cgi/content/short/218/10/3436?rss=1

Source: Journal of Cell Biology - October 6, 2019 Category: Cytology Authors: Klapproth, S., Bromberger, T., Türk, C., Krüger, M., Moser, M. Tags: Adhesion, Cell Signaling, Biochemistry Articles Source Type: research

More News: Biochemistry | Biology | Cytology