10PDevelopment of chimeric antigenic receptor (CAR) against VEGFR2 for solid tumour treatment

ConclusionsThe cytotoxicity assay showed that the VEGFR2-overexpressed FS293 cells were apparently killed by VEGFR2-CART cells. The antitumor effects of the VEGFR2-CART cells have been proved in a murine tumor model, suggesting that targeting VEGFR2 with CART cells can be a novel strategy in cancer immunotherapy.Legal entity responsible for the studyDevelopment Center for Biotechnology.FundingThe government of the Republic of China (Taiwan).DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research