15PTr1-like cells in human peripheral blood are part of the T effector memory pool and are preferentially stimulated via CD55

ConclusionsWe have also demonstrated that these cells respond specifically to costimulation via CD97-CD55 to drive proliferation and maintain the IL-10 single positive, Tr1 phenotype outlined above. This supports the idea that once differentiated from na ïve precursors, Tr1-like cells respond to CD55 costimulation to maintain a small (<5%) pool with a committed IL-10+ IL-4-IFN- γ- phenotype.Legal entity responsible for the studyThe University of Nottingham.FundingThe Commonwealth Scholarships Commission, London.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research