259PProgesterone receptor isoform ratio dictates antiprogestins/progestins effects on metastatic breast cancer models

ConclusionsProgestins/antiprogestins stimulate or inhibit, respectively tumor growth/metastasis of mammary carcinomas with high PRA/PRB ratio, and they may exert opposite effects in tumors with low PRA/PRB ratio. These findings highlight the relevance of evaluating PR isofor.m ratio prior to PR ligand treatment on human breast cancer.Legal entity responsible for the studyCONICET.FundingCONICET; INC, ANPCYT.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research