22PXAF1 and ZNF313 complex stimulates ER stress-induced apoptosis via direct GRP78 inhibition

ConclusionsConclusion: XAF1 sensitizes cells to ER stress and drives apoptotic switch of UPR function away from cell cycle arrest by directly antagonizing GRP78 through the assembly of a ZNF313-mediated destruction complex. Our study identifies first a cell-fate decisions function of XAF1 under ER stress conditions.Legal entity responsible for the studySung-Gil Chi.FundingBK.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research