Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice [Research Articles]

In conclusion, ANGPTL4 deficiency increases lipid uptake and respiration in macrophages without affecting LPL protein levels. Compared with the absence of ANGPTL4, low levels of N-terminal ANGPTL4 mitigate the development of chylous ascites and an acute-phase response in mice.

Source: The Journal of Lipid Research - September 30, 2019 Category: Lipidology Authors: Oteng, A.-B., Ruppert, P. M. M., Boutens, L., Dijk, W., van Dierendonck, X. A. M. H., Olivecrona, G., Stienstra, R., Kersten, S. Tags: Research Articles Source Type: research