Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging [Cancer Diagnostics]

CONCLUSIONS:
MALDI-MSI provides novel insights into the pathophysiology of ACC. Steroid hormone sulfation may be used for prognostication and treatment stratification. Sulfation-related metabolic reprogramming may be of relevance also in conditions beyond the rare ACC and can be directly investigated by the use of MALDI-MSI.

Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Sun, N., Kunzke, T., Sbiera, S., Kircher, S., Feuchtinger, A., Aichler, M., Herterich, S., Ronchi, C. L., Weigand, I., Schlegel, N., Waldmann, J., Candida Villares Fragoso, M., Whitsett, T. G., Gill, A. J., Fassnacht, M., Walch, A., Kroiss, M. Tags: Cancer Diagnostics (since 2002) Source Type: research