Detection of Neprilysin-Derived BNP Fragments in the Circulation: Possible Insights for Targeted Neprilysin Inhibition Therapy for Heart Failure [Proteomics and Protein Markers]

CONCLUSIONS:
BNP-neo17 formation is NEP dependent. Considering that BNP-neo17 is generated from the active form of BNP by NEP, we speculate that BNP-neo17 may reflect both the NEP activity and natriuretic potential and serve for HF therapy guidance.

Source: Clinical Chemistry - September 29, 2019 Category: Chemistry Authors: Feygina, E. E., Artemieva, M. M., Postnikov, A. B., Tamm, N. N., Bloshchitsyna, M. N., Medvedeva, N. A., Katrukha, A. G., Semenov, A. G. Tags: Proteomics and Protein Markers Source Type: research