Do mineral and corn oil serve as potential endocrine disruptors in the gerbil prostate?

Publication date: Available online 27 September 2019Source: Reproductive ToxicologyAuthor(s): Luiz Henrique Alves Guerra, Guilherme Henrique Tamarindo, Silvana Gisele Pegorin de Campos, Sebastião Roberto Taboga, Patricia Simone Leite VilamaiorAbstractVegetable oils are frequently used as a vehicle in the administration of lipophilic drugs in animal tests. However, the composition of these oils may interfere with the results. One alternative to reduce this potential bias is the use of mineral oil, which is not supposed to interfere in the physiology of experimental models, since this oil is considered to be innocous. The present study shows for the first time the effects of the oral administration of corn and mineral on the prostate, demonstrating their interference in homeostasis and revealing their potential to act as endocrine disruptors. Mineral oil treatment increased the expression of AR and ERα and serum estradiol concentrations, while corn oil increased the expression of positive cells for both types of estrogen receptors. The variation in the expression of these hormone receptors resulted in morphological changes in the prostate.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research