ABC-F proteins in mRNA translation and antibiotic resistance

Publication date: Available online 26 September 2019Source: Research in MicrobiologyAuthor(s): Farés Ousalem, Shikha Singh, Olivier Chesneau, John F. Hunt, Grégory BoëlAbstractThe ATP binding cassette protein superfamily comprises ATPase enzymes which are, for the most part, involved in transmembrane transport. Within this superfamily however, some protein families have other functions unrelated to transport. One example is the ABC-F family, which comprises an extremely diverse set of cytoplasmic proteins. All of the proteins in the ABC-F family characterized to date act on the ribosome and are translation factors. Their common function is ATP-dependent modulation of the stereochemistry of the peptidyl transferase center (PTC) in the ribosome coupled to changes in its global conformation and P-site tRNA binding geometry. In this review, we give an overview of the function, structure, and theories for the mechanisms-of-action of microbial proteins in the ABC-F family, including those involved in mediating resistance to ribosome-binding antibiotics.

Source: Research in Microbiology - September 27, 2019 Category: Microbiology Source Type: research