PDR-like ABC systems in pathogenic fungi

Publication date: Available online 25 September 2019Source: Research in MicrobiologyAuthor(s): Alexis Moreno, Atanu Banerjee, Rajendra Prasad, Pierre FalsonAbstractABC transporters of the Pleiotropic Drug Resistance (PDR) family are the main actors of antifungal resistance in pathogenic fungi. While their involvement in clinical resistant strains has been proven, their transport mechanism remains unclear. Notably, one hallmark of PDR transporters is their asymmetry, with one canonical nucleotide-binding site capable of ATP hydrolysis while the other site is not. Recent publications reviewed here show that the so-called “deviant” site is of crucial importance for drug transport and is a step towards alleviating the mystery around the existence of non-catalytic binding sites.

Source: Research in Microbiology - September 26, 2019 Category: Microbiology Source Type: research