Emodin Prevents Ethanol‐Induced Developmental Anomalies in Cultured Mouse Fetus through Multiple Activities

CONCLUSIONSThis study revealed that cotreatment with emodin significantly prevented teratogenesis induced by ethanol, not only by modulating hypoxia and antioxidant enzymes, but also by attenuating the enhanced levels of TNF‐α and caspase 3 in cultured embryos. Therefore, emodin may be an effective preventive agent for ethanol‐induced teratogenesis.

Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - May 21, 2013 Category: Perinatology & Neonatology Authors: Jung‐Min Yon, Chunmei Lin, Ki‐Wan Oh, Hong‐Seok Baek, Beom Jun Lee, Young Won Yun, Sang‐Yoon Nam Tags: Research Article Source Type: research