Closed system RT-qPCR as a potential companion diagnostic test for immunotherapy outcome in metastatic melanoma

ConclusionsIndividual immunotherapy panel markersCD274, PDCD1LG2, CD8A,IRF1 and a combinedL1/L2 mRNA levels show promising associations with melanoma immunotherapy outcome. The turnaround time of the test (2  h) and easy standardization of the platform makes this an attractive approach for further study in the search for predictive biomarkers for ICI.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research