Characterization of CD79αcy+ cells in placentas from ruminants

Publication date: Available online 13 September 2019Source: Veterinary Immunology and ImmunopathologyAuthor(s): Germán J. Cantón, Alex Schock, Noelita Melo de Sousa, Jean-François Beckers, Francesca ChianiniAbstractPrevious work carried out to characterise different immune cells in ruminant placentas found strong CD79αcy nuclear labelling in cells histologically resembling trophoblast cells. In the attempt to characterize this cell population, placentomes collected from cattle, sheep and water buffaloes were examined by immunohistochemistry with single and double labelling using monoclonal antibodies (mAb) against B lymphocytes and trophoblast cells. Most CD79αcy + cells co-expressed placental lactogen or cytokeratin and were CD21 and MHC class II negative strongly suggesting they do not have a B cell origin. However, a potential immunological role of these cells cannot be ruled out and it is currently unknown if the findings described may have an impact on physiological knowledge, health, and or diseases pathogenesis in ruminants
Source: Veterinary Immunology and Immunopathology - Category: Veterinary Research Source Type: research