Involvement of l-Lactate in Hippocampal Dysfunction of Type I Diabetes

Publication date: Available online 13 September 2019Source: Journal of Pharmacological SciencesAuthor(s): Riho Kobayashi, Junya Maruoka, Hiroaki Norimoto, Yuji Ikegaya, Kazuhiko Kume, Masahiro OhsawaAbstractHippocampal neurons play a crucial role in memory formation. Accumulating evidence raises the possibility that hippocampal sharp-wave ripples (SW-Rs) are involved in memory consolidation. Here, we examined in an animal model of diabetes and found the amplitude of SW-Rs in diabetic mice were smaller than control group and were rescued by acute application of L-lactate, a major neural energy source. The cognitive impairment in diabetic mice was alleviated by intracerebroventricular L-lactate treatment. Our results suggested that L-lactate is important for hippocampal dysfunction in diabetes.
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research