ProBNP That Is Not Glycosylated at Threonine 71 Is Decreased with Obesity in Patients with Heart Failure [Current Issues in Laboratory Medicine]

CONCLUSIONS:
Increased BMI is associated with decreased concentrations of proBNP not glycosylated at T71. Decreased proBNP substrate amenable to processing could partially explain the lower NT-proBNP and BNP concentrations observed in obese individuals, including those presenting with HF.

Source: Clinical Chemistry - September 2, 2019 Category: Chemistry Authors: Lewis, L. K., Raudsepp, S. D., Prickett, T. C. R., Yandle, T. G., Doughty, R. N., Frampton, C. M., Pemberton, C. J., Richards, A. M. Tags: Current Issues in Laboratory Medicine Source Type: research