Platelet hyaluronidase-2 regulates the early stages of inflammatory disease in colitis

In this study, we provide evidence that HA catabolism is disrupted in human intestinal microvascular endothelial cells isolated from patients with IBD. Furthermore, mice deficient in HYAL2 are more susceptible to an acute model of colitis, and this increased susceptibility is abrogated by transfusion of HYAL2-competent platelets. Finally, we show that platelets, via HYAL2-dependent degradation of endothelial HA, regulate the early stages of inflammation in colitis by limiting leukocyte extravasation.

Source: Blood - August 28, 2019 Category: Hematology Authors: Petrey, A. C., Obery, D. R., Kessler, S. P., Zawerton, A., Flamion, B., de la Motte, C. A. Tags: Immunobiology and Immunotherapy, Platelets and Thrombopoiesis Source Type: research