The PHD finger of Spp1 mediates histone modification cross-talk

Binding of the Spp1 PHD finger to histone H3K4me3 is sensitive to adjacent post-translational modifications in the histone tail. This commentary discusses the findings of He and colleagues [Biochem. J. 476, 1957–1973] which show that the PHD finger binds to H3K4me3 in a selective manner which is conserved in the Saccharomyces pombe and mammalian orthologues of Spp1.

Source: Biochemical Journal - August 27, 2019 Category: Biochemistry Authors: Musselman, C. A., Kutateladze, T. G. Tags: Commentaries Source Type: research