A gate-keeping test for selecting adaptive interventions under general designs of sequential multiple assignment randomized trials

This article proposes a method to overcome limitations in current methods that address multiple comparisons of adaptive interventions embedded in sequential multiple assignment randomized trial (SMART) designs. Because a SMART typically consists of numerous adaptive interventions, inferential procedures based on pairwise comparisons of all may suffer a substantial loss in power after accounting for multiplicity. Meanwhile, traditional methods for multiplicity adjustments in comparing non-adaptive interventions require prior knowledge of correlation structures, which can be difficult to postulate when analyzing SMART data of adaptive interventions.
Source: Contemporary Clinical Trials - Category: Radiology Authors: Tags: Full Length Article Source Type: research