Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases

Conclusion: We demonstrated that the specific tissue remodeling product of MMPs-degraded biglycan, namely the neo-epitope BGM, is correlated with pathological ECMR. This assay represents both a novel marker of ECM turnover and a potential new tool to elucidate biglycan role during the pathological processes associated with ECMR.
Source: Fibrogenesis and Tissue Repair - Category: Biomedical Science Authors: Source Type: research