Biglycan fragmentation in pathologies associated with extracellular matrix remodeling by matrix metalloproteinases
Conclusion:
We demonstrated that the specific tissue remodeling product of MMPs-degraded biglycan, namely the neo-epitope BGM, is correlated with pathological ECMR. This assay represents both a novel marker of ECM turnover and a potential new tool to elucidate biglycan role during the pathological processes associated with ECMR.
Source: Fibrogenesis and Tissue Repair - Category: Biomedical Science Authors: Federica GenoveseNatasha BarascukLise LarsenMartin LarsenArkadiusz NawrockiYili LiQinlong ZhengJianxia WangSanne VeidalDiana LeemingMorten Karsdal Source Type: research
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