Effect of Lipopolysaccharide on Cell Proliferation and Vascular Endothelial Growth Factor Secretion of Periodontal Ligament Stem Cells

ConclusionsLPS reduced cell proliferation and VEGF secretion of PDLSCs, suggesting that periodontal pathogens might reduce the capability of PDLSCs in periodontal regeneration. Yet, LPS treated PDLSCs remained viable and VEGF secretion increased significantly over time. Further research is needed to study the potential use of PDLSCs in periodontal regeneration and the relationship of biofilm LPS accumulations.
Source: The Saudi Dental Journal - Category: Dentistry Source Type: research