Energy coupling in ABC exporters

Publication date: Available online 20 August 2019Source: Research in MicrobiologyAuthor(s): Hendrik W. van Veen, Himansha Singh, Kelvin Agboh, Lisa A. Fagg, Dawei Guo, Brendan Swain, Robbin F. de Kruijf, Charlotte GuffickAbstractMultidrug transporters are important and interesting molecular machines that extrude a wide variety of cytotoxic drugs from target cells. This review summarizes novel insights in the energetics and mechanisms of bacterial ATP-binding cassette multidrug transporters as well as recent advances connecting multidrug transport to ion and lipid translocation processes in other membrane proteins.
Source: Research in Microbiology - Category: Microbiology Source Type: research