Study on synthesis of key squalamine intermediate 7α, 24R-dihydroxy-5α-cholestan-3-one

Publication date: November 2019Source: Steroids, Volume 151Author(s): Shuai Zhou, Yang Zheng, Beibei Yang, Jiawei Zhong, Haijian ShiAbstractA facile novel strategy has been developed to obtain a key intermediate of squalamine, 7α, 24R -dihydroxy-5α-cholestan-3-one, starting from methyl Δ5-3β-hydroxycholanate. The pure product was successfully synthesized and separated from the C-24 position epimers in good purity, d.e.% and yield.Graphical abstractA key intermediate of squalamine, 7α, 24R-dihydroxy-5α-cholestan-3-one has been developed starting from methyl Δ5-3β-hydroxycholanate.
Source: Steroids - Category: Drugs & Pharmacology Source Type: research