Synthesis, physico-chemical studies and biological evaluation of new metal complexes with some pyrazolone derivatives

Publication date: Available online 16 August 2019Source: Journal of Saudi Chemical SocietyAuthor(s): Ahmed M. Ramadan, Asma A. Alshehri, Samir BondockAbstractA series of N-substituted-4-thiocarbamoyl-5-pyrazolone derivatives (HL1-HL4) is presented as chelating agents for complexation with Fe(III), Ni(II) and Cu(II) metal ions. The synthesized pyrazolone ligands and their newly metal complexes are characterized by different spectral and analytical methods such as UV-Vis, IR, 1H NMR, 13C NMR, ESR, MS, magnetic measurement, and TGA. The spectral data reveal that ligands coordinated to metal ions in a bidentate pattern via O & N atoms of the OH group at C(5) and thiocarbamoyl (−CSNHR) at C(4) of the pyrazolone ring. Also, the analytical data suggest the stoichiometries 2:3 (M:L) for both Cu(II) & Ni(II) complexes and 1:3 for Fe(III) complexes. Besides, the normal magnetic moments values for Fe(III) complexes confirm high spin octahedral structure while the diamagnetic nature of all Ni(II) complexes is consistent with square planar geometry. However, the subnormal magnetic values for Cu(II) complexes suggest the proposal of their binuclear structures. The ESR spectra of the Cu(II) complexes support the distorted square planar geometry with a considerably strong intradimeric spin-exchange interaction. Moreover, the anticancer, antimicrobial and antifungal activities are screened. Among the synthesized compounds, HL4 ligand exhibits a significant broad spectrum of action against G...
Source: Journal of Saudi Chemical Society - Category: Chemistry Source Type: research