Synovium-derived stromal cell-induced osteoclastogenesis: A potential osteoarthritis trigger

Conclusions: Osteoclastogenic differentiation capability of PBMCs from OA subjects, also induced by B synoviocytes has been already documented. Here we hypothesized that SDSCs, generally considered for their regenerative potential in cartilage lesions, have also a role in the onset/maintenance of OA. Clinical Relevance: Our observations may represent an interesting opportunity for the development of a holistic approach for OA treatment, that considers the multifaceted capability of MSCs in relation to the environment.

Source: Clinical Science - August 14, 2019 Category: Biomedical Science Authors: Dicarlo, M., Teti, G., Cerqueni, G., Iezzi, I., Gigante, A., Falconi, M., Mattioli-Belmonte, M. Tags: PublishAheadOfPrint Source Type: research