An etiological role for the Epstein-Barr virus in the pathogenesis of classical Hodgkin lymphoma

Although a pathogenic role for the Epstein-Barr virus (EBV) is largely undisputed for tumors that are consistently EBV genome positive (eg, nasopharyngeal carcinoma, endemic Burkitt lymphoma), this is not the case for classical Hodgkin lymphoma (cHL), a tumor with only a variable EBV association. In light of recent developments in immunotherapeutics and small molecules targeting EBV, we believe it is now timely to reevaluate the role of EBV in cHL pathogenesis.

Source: Blood - August 14, 2019 Category: Hematology Authors: Murray, P. G., Young, L. S. Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia, Blood Spotlight Source Type: research