The SUF system: An ABC ATPase-dependent protein complex with a role in Fe-S cluster biogenesis

Publication date: Available online 14 August 2019Source: Research in MicrobiologyAuthor(s): Pierre Simon Garcia, Simonetta Gribaldo, Béatrice Py, Frédéric BarrasAbstractIron-sulfur (Fe-S) clusters are considered one of the most ancient and versatile inorganic cofactors present in the three domains of life. Fe-S clusters can act as redox sensors or catalysts and are found to be used by a large number of functional and structurally diverse proteins. Here, we cover current knowledge of the SUF multiprotein machinery that synthesizes and inserts Fe-S clusters into proteins. Specific focus is put on the ABC ATPase SufC, which contributes to building Fe-S clusters, and appeared early on during evolution.

Source: Research in Microbiology - August 14, 2019 Category: Microbiology Source Type: research