Acetate transiently inhibits myocardial contraction by increasing mitochondrial calcium uptake

Conclusions:
Lehninger and others have previously demonstrated that the anions of weak aliphatic acids such as acetate stimulate Ca2+ uptake in isolated mitochondria. Here we show that this effect of acetate appears to extend to isolated cardiac myocytes where it transiently modulates cell contraction.

Source: BMC Physiology - December 9, 2014 Category: Physiology Authors: James SchooleyAryan NamboodiriRachel CoxRolf BüngerThomas Flagg Source Type: research