Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children

Publication date: Available online 12 August 2019Source: Reproductive ToxicologyAuthor(s): Kristin J. Marks, Zuha Jeddy, W. Dana Flanders, Kate Northstone, Abigail Fraser, Antonia M. Calafat, Kayoko Kato, Terryl J. HartmanAbstractPerfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG). We used data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal check-ups; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by pre-pregnancy body mass index. Associations of maternal PFAS concentrations with absolute GWG were null. Ten percent higher perfluorooctane sulfonic acid (PFOS) was associated with GWG of -0.03 kg (95% CI: -0.11, 0.06) and -0.12 kg (95% CI: -0.30, 0.06) among under-/normal weight and overweight/obese mothers, respectively. Overall, findings suggest no association between maternal PFAS concentrations and GWG.
Source: Reproductive Toxicology - Category: Toxicology Source Type: research