Optimization of a nonviral transfection system to evaluate Cox‐2 controlled interleukin‐4 expression for osteoarthritis gene therapy in vitro

ConclusionsWe consider that this approach has significant potential for translation into a useful anti‐inflammation therapy. Molecular tools such as the described therapeutic plasmid pave the way for a local‐controlled, self‐limiting gene therapy. Copyright © 2014 John Wiley & Sons, Ltd.

Source: The Journal of Gene Medicine - December 9, 2014 Category: Genetics & Stem Cells Authors: Annemarie Lang, Johannes Neuhaus, Moritz Pfeiffenberger, Erik Schröder, Igor Ponomarev, Yvonne Weber, Timo Gaber, Michael F. G. Schmidt Tags: Research Article Source Type: research