Molecule Linked to Rare Blood Type

In addition to the familiar ABO blood group system, there are more than 30 others. Scientists now better understand the molecular underpinnings of a rare blood type called Vel-negative. An international research team has shown that a previously unknown protein, SMIM1, is missing from the red blood cells of individuals who are Vel-negative. About 1 in 2,500 people have this blood type, and they are at great risk for potentially fatal complications from successive transfusions. Based on these findings, the researchers have developed two DNA-based tests to assist health professionals in detecting and treating Vel-negative patients.

Source: NIGMS Biomedical Beat - April 18, 2013 Category: Research Source Type: news