The Protective Effects of Dexmedetomidine on Ischemic Brain Injury: A Meta-analysis

(Abstracted from J Clin Anesth, 40:25–32, 2017) The inflammatory cascade mediated by neuroendocrine hormones and proinflammatory mediators, caused by disordered hemodynamics or adverse stress, has been implicated in the pathophysiology of ischemic brain injury. The α2-adrenoceptor agonist dexmedetomidine (DEX) inhibits inflammatory and neuroendocrine responses, but comprehensive meta-analysis to estimate neuroprotection of α2-agonists is still lacking and could guide clinical treatment and prognosis.
Source: Survey of Anesthesiology - Category: Anesthesiology Tags: Neuroanesthesia Source Type: research