mRNA encoding WAVE-Arp2/3 associated proteins is co-localised with foci of active protein synthesis at the leading edge of MRC5 fibroblasts during cell migration

In this study we show that mRNAs encoding some structural and regulatory components of the WAVE complex are localised to the leading edge of the cell and associated with sites of active translation. Furthermore we demonstrate that steady state levels of ArpC2 and Rac1 proteins increase at the leading edge during cell spreading suggesting that localised protein synthesis has a pivotal role in controlling cell spreading and migration.

Source: BJ Cell - March 4, 2013 Category: Biochemistry Authors: M Willett, M Brocard, H J Pollard, S J Morley Tags: BJ Cell Source Type: research