The complete N-terminal extension of heparin cofactor II is required for maximal effectiveness as a thrombin exosite 1 ligand

An isolated form of N-terminal acidic extension of Heparin cofactor II (HCII 1-75) binds thrombin with a higher affinity than glycosaminoglycans (GAGs), suggesting that this region of Heparin cofactor II (HCII) is required for binding of thrombin exosite 1.

Source: BMC Biochemistry - March 7, 2013 Category: Biochemistry Authors: Amanda BoyleLeigh RoddickVarsha BhaktaMelissa LambourneMurray JunopPatricia LiawJeffrey WeitzWilliam Sheffield Source Type: research