Study on Synthesis of Key Squalamine intermediate 7α, 24R -Dihydroxy-5α-cholestan-3-one

Publication date: Available online 7 August 2019Source: SteroidsAuthor(s): Shuai Zhou, Yang Zheng, Beibei Yang, Jiawei Zhong, Haijian ShiAbstractA facile novel strategy has been developed to obtain a key intermediate of squalamine, 7α, 24R -dihydroxy-5α-cholestan-3-one, starting from methyl Δ5-3β-hydroxycholanate. The pure product was successfully synthesized and separated from the C-24 position epimers in good purity, d.e.% and yield.Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research