Brassinosteroid analogues from the fruiting bodies of Laetiporus sulphureus and their anti-inflammatory activity

Publication date: Available online 7 August 2019Source: SteroidsAuthor(s): Qosimjon Khalilov, Liya Li, Yushuang Liu, Wei Liu, Sodik Numonov, Haji Akber Aisa, Tao YuanAbstractThree new brassinosteroid analogues, named sulphurenolide A, sulphurenolide B and sulphurenolide C, were isolated from the methanolic extract of fruiting bodies of Laetiporus sulphureus. Their structures were established on the basis of extensive spectroscopic analysis (1D, 2D NMR, and HRESIMS) and ECD calculation. Sulphurenolides A and B are a pair of C-20 epimer, and sulphurenolide B represents the first naturally occurring 20R-brassinosteroid. Moreover, sulphurenolides A−C are firstly reported 5-hydroxylation and homo-6-oxa derivatives of brassinosteroids from natural sources. Anti-inflammatory assay revealed that sulphurenolides B and C exhibited significant inhibitory effects on NO production in lipopolysaccharide-induced RAW264.7 cells, and sulphurenolide C showed stronger inhibition than that of positive control, minocycline.Graphical abstract
Source: Steroids - Category: Drugs & Pharmacology Source Type: research