Colorectal cancer cell-derived CCL20 recruits regulatory T cells to promote chemoresistance via FOXO1/CEBPB/NF- κB signaling

ConclusionsCRC cell-secreted CCL20 can recruit Tregs to promote chemoresistance via FOXO1/CEBPB/NF- κB signaling, indicating that the FOXO1/CEBPB/NF-κB/CCL20 axis might provide a promising target for CRC treatment.

http://link.springer.com/10.1186/s40425-019-0701-2

Source: Journal for Immunotherapy of Cancer - August 7, 2019 Category: Cancer & Oncology Source Type: research