miR-448 targets IDO1 and regulates CD8 + T cell response in human colon cancer

ConclusionOur findings indicated that IDO1 suppressed the CD8+ T cell response in colon cancer. miR-448, as a tumor-suppressive miRNA, enhanced the CD8+ T cell response by inhibiting IDO1 expression. The results provide a theoretical basis for the development of new immunotherapy for the treatment of colon cancer.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research