Natural killer T cell activation increases iNOS + CD206 - M1 macrophage and controls the growth of solid tumor

ConclusionsWe showed that activation of NKT cell with α-GalCer modulates the frequency of M1-macrophages and effector Th1 cells in the secondary lymphoid tissues and tumor microenvironment and inhibit tumor growth. The finding suggests that activation of NKT cells with α-GalCer may provide an effective anti-cancer outcome.

http://link.springer.com/10.1186/s40425-019-0697-7

Source: Journal for Immunotherapy of Cancer - August 5, 2019 Category: Cancer & Oncology Source Type: research