Neurexin nanoclusters: A novel structure at presynaptic terminals

The trans-synaptic cell adhesion molecule neurexin regulates synaptic functions but its high-resolution subcellular localization and dynamics were unknown. Trotter et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201812076) describe previously unrecognized nanoscale clusters of neurexin-1 in presynaptic terminals and their regulation by ADAM10-mediated proteolysis.

http://jcb.rupress.org/cgi/content/short/218/8/2442?rss=1

Source: Journal of Cell Biology - August 4, 2019 Category: Cytology Authors: Kawaguchi, D., Gotoh, Y. Tags: Spotlight Source Type: research

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