A novel Phosphatidylinositol 3-Kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes

Conclusions: The constitutive activation of PI3Ks and thus the exclusion of FOXO transcription factors from the nucleus is a key feature of breast cancer. Our results presented here highlight that PI3K inhibition activates specific FOXO-dependent genes that mediate cell cycle arrest in breast cancer cells.

http://breast-cancer-research.com/content/16/6/482

Source: Breast Cancer Research - December 9, 2014 Category: Cancer & Oncology Authors: Richard HillRavi KalathurSergio CallejasLaura ColaçoRicardo BrandãoBeatriz SereldeAntonio CebriáCarmen Blanco-AparicioJoaquín PastorMatthias FutschikAna DopazoWolfgang Link Source Type: research