Activities of mitochondrial respiratory chain complexes in platelets of patients with Alzheimer's disease and depressive disorder

Publication date: Available online 1 August 2019Source: MitochondrionAuthor(s): Zdeněk Fišar, Hana Hansíková, Jana Křížová, Roman Jirák, Eva Kitzlerová, Martina Zvěřová, Jana Hroudová, László Wenchich, Jiří Zeman, Jiří RabochAbstractWe analyzed activities of complex I, II, III, and IV, and citrate synthase (CS) in patients with major depressive disorder (MDD) or Alzheimer's disease (AD) presenting with or without depression. Associations of these parameters with disease or disease severity were observed in both AD and MDD; however, mean values of mitochondrial parameters were significantly altered in AD but not in MDD. Potential mitochondrial dysfunction in MDD seems not to be caused by disturbed activity of CS or respiratory complexes. In AD, a decrease in the activity of CS and complex IV may cause mitochondrial dysfunction, whereas an increase in activities of other mitochondrial complexes or their ratios to CS may be an adaptive response. The data indicate that comorbid depression in AD is associated with increased complex II activity. The mitochondrial parameters measured can be included in the panel of biomarkers of AD.
Source: Mitochondrion - Category: Biochemistry Source Type: research